Dosage compensation can also be referred to as chromosome-wide gene dosage compensation, sex chromosome dosage compensation, or X chromosome inactivation. In mammals, dosage compensation is achieved through the inactivation of one of the two X chromosomes in female cells. This process is also called Lyonization or random X-chromosome inactivation. In Drosophila, dosage compensation occurs through the process of dosage compensation complex (DCC) binding to the male X chromosome, increasing transcriptional output to match that of the two X chromosomes in females. Another synonym for dosage compensation is gene dosage balance, which refers to the equal expression of genes across different sex chromosomes or autosomes.