"Most leagued" refers to being strongly associated or connected with someone or something. Antonyms for this phrase would include "unrelated," "dissociated," "disconnected," "unconnected," "independent," and "separate." These words imply a lack of close ties or bonds between two or more entities. For example, two countries could be unrelated in terms of their political ideologies, or two individuals could be independent in their choices and lifestyles. The opposite of being "most leagued" suggests a sense of distance or independence, which could be beneficial or detrimental depending on the context.