Chlortalidone is a commonly used drug in medicine. However, it is known by several synonyms that are equally useful in the field of medicine. Some of the synonyms that refer to the same drug include hygroton, thalitone, and metahydrin. These synonyms are used interchangeably but have the same active ingredient chlortalidone. Chlortalidone is a diuretic medication that helps reduce excess water and salt in the body and is mainly used in the treatment of high blood pressure and edema. By identifying different synonyms for chlortalidone, doctors are better equipped to diagnose and treat ailments that require the use of this medication.