A second site mutation is a genetic alteration that occurs at a location in the DNA sequence other than the original mutation site. In other words, it is a mutation that happens at a different spot, or "second site," in the genetic code. Synonyms for this term can include "secondary mutation," "subsequent mutation," or "new mutation." Understanding second site mutations is important in many fields, including genetic research and medicine. These mutations can affect the severity and course of inherited disorders, and they can also impact drug resistance in illnesses like cancer. As scientists continue to investigate the mechanisms behind genetic mutations, the terminology used to describe them may evolve as well.